Catalysis and Peptide Research Unit
The interests of the unit’s research group span the disciplines of organic synthesis, asymmetric catalysis, peptide drug design and computational chemistry. Current projects are:
• Synthesis and evaluation of inhibitors targeting HIV and TB
• Synthesis of classes of chiral ligands and catalysts
• Experimental and theoretical research about the fundamental aspects of peptide folding.
• Various computational projects into mechanistic effects of our synthetic projects.
Strategies for prevention and containment on antibiotic resistance based on surveillance, risk factors, clinical significance, infection control, pharmaco-economics and drug pharmacokinetics and pharmacodynamics
Molecular biology/Genetics of bacterial resistance
WHO Collaborating Centre for Pharmaceutical Policy and Evidence Based Practice
To conduct evidence based policy analysis and strengthen/develop conceptual innovation in the area of curriculum and pedagogy in pharmaceutical sciences and pharmaceutical policy related to particular topics of interest to WHO. The focus will be on evidence for low and middle income countries.
Molecular Modeling & Drug Design Research Group
Covers a wide range of computational and molecular modeling approaches with main focus on drug design and understanding of bio-related systems from different disciplines such as phytochemistry, pharmaceutics, medicinal chemistry, biochemistry, genetics and protein sciences.
Synthetic and Medicinal Chemistry Research Group
Target Based Drug Design (HIV, TB and Cancer)
Strategies to develop new efficient synthetic methodologies to synthesize biologically important scaffolds.
Design and Synthesis of novel conducting polymers as potential Biosensors
Design and development of nanoparticle-based electrodes.
Protein systems in health & disease
Angiogenesis & in vitro tumour models
Neuro-psycho-immunology of auto-immune diseases
Indigenous anti-cancer candidate compounds
Transcription factors in diabetes
Molecular and clinical pharmacology research unit
Research theme: Metabolic syndrome in diabetes and Cardiovascular diseases
Novel Drug Delivery Systems
Design and Physicochemical/mechanical/molecular/biological evaluation of novel drug delivery systems e.g. sustained release pellets, nanoparticles, nanomicelles, nanofibers and buccal patches/films/tablets/microspheres/wafers.
1.Maximizing the therapeutic potential of clofazimine for tuberculosis: experimental and clinical approaches.
2.Indigenous knowledge systems and HIV/AIDS.
Researcher: Mr Olubunmi Adebiyi
Summary: Naringin is a chemical compound isolated from grapefruit. The study aimed to investigate the potential therapeutic benefits of naringin in ameliorating oxidative stress-induced cardiac and renal damage. Naringin has been identified to have a variety of effects ranging from antioxidant to anti-inflammatory and anti-mutagenic potentials. The study investigated the usefulness or otherwise of the antioxidant potentials of naringin in preventing or alleviating oxidative stress induced diabetic cardiomyopathy.