Professor Gert Kruger

Professor Gert Kruger

Person

Professor Gert Kruger

 

Telephone

+27 (031) 260 1845

Email

Kruger@ukzn.ac.za

Campus

Westville

Research Interests

Polycyclic cage chemistry, NMR structure elucidation and computational chemistry

Designation

Research Professor
  Biosketch

        Gert Kruger is a senior researcher in the Peptide and Catalysis Research Unit at the Westville Campus, UKZN. His research interests include Health Sciences, Organic Chemistry, and Pharmaceutical Chemistry. Kruger’s research specialties include chiral synthesis; peptide synthesis; cage compounds; NMR of cage compounds; TB-cage drugs; and cage anti HIV-PR inhibitors.

 Researchgate Profile
 List of Publications  

Gert Kruger  papers

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Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

Ramesh S, Cherkupally P, de la Torre BG, Govender T, Kruger HG, Albericio F.

Amino Acids. 2014 Jun 25. [Epub ahead of print]

PMID: 24961648

 Proline N-oxides: modulators of the 3D conformation of linear peptides through “NO-turns”.

Farahani MD, Honarparvar B, Albericio F, Maguire GE, Govender T, Arvidsson PI, Kruger HG.

Org Biomol Chem. 2014 Jul 7;12(25):4479-90. doi: 10.1039/c4ob00433g.

PMID: 24849849

Solid-phase peptide synthesis (SPPS), C-terminal vs. side-chain anchoring: a reality or a myth.

Cherkupally P, Acosta GA, Ramesh S, De la Torre BG, Govender T, Kruger HG, Albericio F.

Amino Acids. 2014 Aug;46(8):1827-38. doi: 10.1007/s00726-014-1746-7. Epub 2014 Apr 26.

PMID: 24770904

 Peptide synthesis, characterization and 68Ga-radiolabeling of NOTA-conjugated ubiquicidin fragments for prospective infection imaging with PET/CT.

Ebenhan T, Chadwick N, Sathekge MM, Govender P, Govender T, Kruger HG, Marjanovic-Painter B, Zeevaart JR.

Nucl Med Biol. 2014 May-Jun;41(5):390-400. doi: 10.1016/j.nucmedbio.2014.02.001. Epub 2014 Feb 13.

PMID: 24630816

 The impact of active site mutations of South African HIV PR on drug resistance: Insight from molecular dynamics simulations, binding free energy and per-residue footprints.

Ahmed SM, Maguire GE, Kruger HG, Govender T.

Chem Biol Drug Des. 2014 Apr;83(4):472-81. doi: 10.1111/cbdd.12262.

PMID: 24267738

Organocatalyzed stereospecific C-C bond formation of ß-lactams.

Pawar SA, Alapour S, Khanyase S, Cele ZE, Chitti S, Kruger HG, Govender T, Arvidsson PI. Org Biomol Chem. 2013 Dec 28;11(48):8294-7. doi: 10.1039/c3ob41858h. Epub 2013 Nov 11.

PMID: 24217690

{2-[(1,3-Benzo-thia-zol-2-yl)meth-oxy]-5-fluoro-phen-yl}(4-chloro-phen-yl)methanone.

Venugopala KN, Nayak SK, Govender T, Kruger HG, Maguire GE. Acta Crystallogr Sect E Struct Rep Online. 2013 Jun 8;69(Pt 7):o1007-8. doi: 10.1107/S1600536813014621. eCollection 2013.

PMID: 24046594

 Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivity.

Honarparvar B, Govender T, Maguire GE, Soliman ME, Kruger HG.

Chem Rev. 2014 Jan 8;114(1):493-537. doi: 10.1021/cr300314q. Epub 2013 Sep 11. No abstract available.

PMID: 24024775

 Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands.

Chelopo MP, Pawar SA, Sokhela MK, Govender T, Kruger HG, Maguire GE.

Eur J Med Chem. 2013 Aug;66:407-14. doi: 10.1016/j.ejmech.2013.05.048. Epub 2013 Jun 12.

PMID: 23827181

 [2-(1,3-Benzothia-zol-2-ylmeth-oxy)-5-bromo-phen-yl](4-chloro-phen-yl)methanone.

Nayak SK, Venugopala KN, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2013 Jan 1;69(Pt 1):o70. doi: 10.1107/S1600536812049756. Epub 2012 Dec 12.

PMID: 23476451

 Methyl 2-(2,3,5-trimethyl-1,1-dioxo-2H-1?(6),2,6-thia-diazin-4-yl)benzoate.

Bhatt N, Bhatt P, Nimavat K, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2012 Dec 1;68(Pt 12):o3360. doi: 10.1107/S1600536812046375. Epub 2012 Nov 17.

PMID: 23476194

Linear and cyclic glycopeptide as HIV protease inhibitors.

Pawar SA, Jabgunde AM, Maguire GE, Kruger HG, Sayed Y, Soliman ME, Dhavale DD, Govender T.

Eur J Med Chem. 2013 Feb;60:144-54. doi: 10.1016/j.ejmech.2012.11.018. Epub 2012 Nov 29.

PMID:23291117

 (2-(Benzo[d]thia-zol-2yl-meth-oxy)-5-chloro-phen-yl)(phen-yl)methanone.

Venugopala KN, Nayak SK, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3125. doi: 10.1107/S1600536812041888. Epub 2012 Oct 13.

PMID: 23284450

 2-(3,5-Dimethyl-1,1-dioxo-2H-1?(6),2,6-thia-diazin-4-yl)benzoic acid.

Bhatt N, Bhatt P, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2012 Oct 1;68(Pt 10):o2859. doi: 10.1107/S1600536812037026. Epub 2012 Sep 5.

PMID: 23125661

Comparison of the molecular dynamics and calculated binding free energies for nine FDA-approved HIV-1 PR drugs against subtype B and C-SA HIV PR.

Ahmed SM, Kruger HG, Govender T, Maguire GE, Sayed Y, Ibrahim MA, Naicker P, Soliman ME.

Chem Biol Drug Des. 2013 Feb;81(2):208-18. doi: 10.1111/cbdd.12063. Epub 2012 Nov 19.

PMID: 23017010

Therapeutic peptides.

Albericio F, Kruger HG.

Future Med Chem. 2012 Aug;4(12):1527-31. doi: 10.4155/fmc.12.94. No abstract available.

PMID: 22917241

 (S)-4-tert-Butyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole.

Pawar S, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2012 Aug 1;68(Pt 8):o2487. doi: 10.1107/S160053681203173X. Epub 2012 Jul 18.

PMID: 22904929

 Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors.

Makatini MM, Petzold K, Arvidsson PI, Honarparvar B, Govender T, Maguire GE, Parboosing R, Sayed Y, Soliman ME, Kruger HG.

Eur J Med Chem. 2012 Nov;57:459-67. doi: 10.1016/j.ejmech.2012.06.019. Epub 2012 Jul 16.

PMID: 22867528

 Ethyl 2-(3,5-dimethyl-1,1-dioxo-2H-1?(6),2,6-thia-diazin-4-yl)benzoate.

Bhatt N, Bhatt P, Vyas KB, Nimavat K, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2160. doi: 10.1107/S1600536812024907. Epub 2012 Jun 20.

PMID: 22798832

Interaction of beta-amyloid interactions with peptide functionalized gold nanoparticles.

Hemmaragala NM, Arvidsson PI, Maguire GE, Kruger HG, Govender T.

J Nanosci Nanotechnol. 2012 Mar;12(3):2179-84.

PMID: 22755035

 Novel polycyclic ‘cage’-1,2-diamines as potential anti-tuberculosis agents.

Onajole OK, Coovadia Y, Kruger HG, Maguire GE, Pillay M, Govender T.

Eur J Med Chem. 2012 Aug;54:1-9. doi: 10.1016/j.ejmech.2012.03.041. Epub 2012 Apr 4.

PMID: 22658084

 Nanotechnology and the treatment of HIV infection.

Parboosing R, Maguire GE, Govender P, Kruger HG.

Viruses. 2012 Apr;4(4):488-520. doi: 10.3390/v4040488. Epub 2012 Apr 10. Review.

PMID: 22590683

 Pentacycloundecane-diol-based HIV-1 protease inhibitors: biological screening, 2D NMR, and molecular simulation studies.

Honarparvar B, Makatini MM, Pawar SA, Petzold K, Soliman ME, Arvidsson PI, Sayed Y, Govender T, Maguire GE, Kruger HG. ChemMedChem. 2012 Jun;7(6):1009-19. doi: 10.1002/cmdc.201100512. Epub 2012 Apr 27.

PMID: 22544389

 Synthesis and molecular modelling studies of novel carbapeptide analogs for inhibition of HIV-1 protease.

Pawar SA, Jabgunde AM, Govender P, Maguire GE, Kruger HG, Parboosing R, Soliman ME, Sayed Y, Dhavale DD, Govender T.

Eur J Med Chem. 2012 Jul;53:13-21. doi: 10.1016/j.ejmech.2012.03.027. Epub 2012 Apr 4.

PMID: 22542107

Molecular modeling of T. rangeli, T. brucei gambiense, and T. evansi sialidases in complex with the DANA inhibitor.

Lima AH, Souza PR, Alencar N, Lameira J, Govender T, Kruger HG, Maguire GE, Alves CN. Chem Biol Drug Des. 2012 Jul;80(1):114-20. doi: 10.1111/j.1747-0285.2012.01380.x. Epub 2012 Apr 13.

PMID: 22416952

 (S)-Benzyl 3-phenyl-carbamoyl-1,2,3,4-tetra-hydro-isoquinoline-2-carboxyl-ate.

Naicker T, Chelopo M, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o883. doi: 10.1107/S1600536812007969. Epub 2012 Feb 29.

PMID: 22412734

 Design of ionic liquid 3-methyl-1-sulfonic acid imidazolium nitrate as reagent for the nitration of aromatic compounds by in situ generation of NO(2) in acidic media.

Zolfigol MA, Khazaei A, Moosavi-Zare AR, Zare A, Kruger HG, Asgari Z, Khakyzadeh V, Kazem-Rostami M.

J Org Chem. 2012 Apr 6;77(7):3640-5. doi: 10.1021/jo300137w. Epub 2012 Mar 22.

PMID: 22409592

Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors.

Makatini MM, Petzold K, Alves CN, Arvidsson PI, Honarparvar B, Govender P, Govender T, Kruger HG, Sayed Y, JerônimoLameira, Maguire GE, Soliman ME.

J Enzyme Inhib Med Chem. 2013 Feb;28(1):78-88. doi: 10.3109/14756366.2011.633907. Epub 2012 Feb 17.

PMID: 22339087

 Polycyclic cage structures as lipophilic scaffolds for neuroactive drugs.

Joubert J, Geldenhuys WJ, Van der Schyf CJ, Oliver DW, Kruger HG, Govender T, Malan SF.

ChemMedChem. 2012 Mar 5;7(3):375-84. doi: 10.1002/cmdc.201100559. Epub 2012 Feb 3. Review.

PMID: 22307951

 (S)-Methyl 2-benzamido-3-(3,4-dimeth-oxy-phen-yl)propano-ate.

Naicker T, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2012 Jan;68(Pt 1):o177. doi: 10.1107/S1600536811052767. Epub 2011 Dec 21.

PMID: 22259461

(S)-4-Phenyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole.

Pawar S, Bhatt P, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2012 Jan;68(Pt 1):o176. doi: 10.1107/S1600536811052585. Epub 2011 Dec 21.

PMID: 22259460

 Ethyl 4-(1,3-benzodioxol-5-yl)-6-methyl-2-sulfanylidene-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

Nayak SK, Venugopala KN, Govender T, Kruger HG, Maguire GE, Row TN.

Acta Crystallogr Sect E Struct Rep Online. 2011 Nov;67(Pt 11):o3069-70. doi: 10.1107/S1600536811043649. Epub 2011 Oct 29.

PMID: 22220078

(1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carbothio-amide.

Naicker T, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3441. doi: 10.1107/S1600536811049324. Epub 2011 Nov 25.

PMID: 22199922

 (S)-Methyl 3-(3,4-dimeth-oxy-phen-yl)-2-[2-(diphenyl-phosphan-yl)benzamido]-propano-ate.

Naicker T, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3285. doi: 10.1107/S1600536811047179. Epub 2011 Nov 12.

PMID: 22199790

 Synthesis and NMR elucidation of novel tetrapeptides.

Makatini M, Chetty T, Onajole OK, Govender T, Govender P, Maguire GE, Kruger HG.

J Pept Sci. 2012 Feb;18(2):114-21. doi: 10.1002/psc.1423. Epub 2011 Nov 11.

PMID: 22076961

 N-Benzyl-5-(dimethyl-amino)-naphthalene-1-sulfonamide.

Bhatt P, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2458-9. doi: 10.1107/S1600536811033083. Epub 2011 Aug 27.

PMID: 22065719

 2-[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4-phenyl-1,3-thia-zole.

Pawar S, Katharigatta V, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2722. doi: 10.1107/S1600536811037494. Epub 2011 Sep 30.

PMID: 22065627

 Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors.

Karpoormath R, Sayed Y, Govender P, Govender T, Kruger HG, Soliman ME, Maguire GE.

Bioorg Chem. 2012 Feb;40(1):19-29. doi: 10.1016/j.bioorg.2011.08.002. Epub 2011 Aug 16.

PMID: 21982718

Anti-inflammatory activities of selected synthetic homoisoflavanones.

Shaikh MM, Kruger HG, Bodenstein J, Smith P, du Toit K.

Nat Prod Res. 2012;26(16):1473-82. doi: 10.1080/14786419.2011.565004. Epub 2011 Sep 27.

PMID: 21950651

 Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential antimycobacterial candidates.

Onajole OK, Sosibo S, Govender P, Govender T, van Helden PD, Maguire GE, Mlinaric-Majerski K, Wiid I, Kruger HG.

Chem Biol Drug Des. 2011 Dec;78(6):1022-30. doi: 10.1111/j.1747-0285.2011.01242.x. Epub 2011 Oct 24.

PMID: 21920029

 Ethyl 6-methyl-2-sulfanyl-idene-4-[4-(trifluoro-meth-yl)phen-yl]-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

Nayak SK, Venugopala KN, Govender T, Kruger HG, Maguire GE, Row TN.

Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1559-60. doi: 10.1107/S1600536811019441. Epub 2011 Jun 4.

PMID: 21836973

 Enzymatic activation of a peptide functionalised gold nanoparticle system for prodrug delivery.

Pietersen LK, Govender P, Kruger HG, Maguire GE, Govender T.

J Nanosci Nanotechnol. 2011 Apr;11(4):3075-83.

PMID: 21776673

Total synthesis of a depsidomycin analogue by convergent solid-phase peptide synthesis and macrolactonization strategy for antitubercular activity.

Narayanaswamy VK, Albericio F, Coovadia YM, Kruger HG, Maguire GE, Pillay M, Govender T.

J Pept Sci. 2011 Oct;17(10):683-9. doi: 10.1002/psc.1389. Epub 2011 Jul 18.

PMID: 21766389

 (1S,3S)-Methyl 6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

Naicker T, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1501. doi: 10.1107/S1600536811018782. Epub 2011 May 25.

PMID: 21754868

 N-(Adamantan-1-yl)-2-chloro-acetamide.

Onajole OK, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1444. doi: 10.1107/S1600536811018046. Epub 2011 May 20.

PMID: 21754821

 (1S,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

Naicker T, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1403. doi: 10.1107/S1600536811017430. Epub 2011 May 14.

PMID: 21754788

6,7-Dimeth-oxy-3-meth-oxy-carbonyl-1-(2-meth-oxy-phen-yl)-3,4-dihydro-isoquinoline 2-oxide.

Naicker T, Govender T, Kruger HG, Maguire GE. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1352. doi: 10.1107/S1600536811016539. Epub 2011 May 7.

PMID: 21754746

(S)-2-Benzyl-N-(2,6-diisopropyl-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide.

Naicker T, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 May 1;67(Pt 5):o1106. doi: 10.1107/S1600536811012554. Epub 2011 Apr 13.

PMID: 21754424

 Methyl 1-cyclo-hexyl-6,7-dimeth-oxy-3,4-dihydro-isoquinoline-3-carboxyl-ate.

Naicker T, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 1;67(Pt 4):o883. doi: 10.1107/S1600536811009032. Epub 2011 Mar 15.

PMID: 21754160

 Benzyl 5-hy-droxy-4-oxapenta-cyclo-[5.4.1.0.0.0]dodecane-3-carboxyl-ate.

Karpoormath R, Naicker T, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 1;67(Pt 4):o877. doi: 10.1107/S1600536811009020. Epub 2011 Mar 12.

PMID: 21754154

Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: a hybrid 2D NMR and docking/QM/MM/MD approach.

Makatini MM, Petzold K, Sriharsha SN, Ndlovu N, Soliman ME, Honarparvar B, Parboosing R, Naidoo A, Arvidsson PI, Sayed Y, Govender P, Maguire GE, Kruger HG, Govender T.

Eur J Med Chem. 2011 Sep;46(9):3976-85. doi: 10.1016/j.ejmech.2011.05.071. Epub 2011 Jun 7.

PMID: 21741133

 3-Benzyl-5,7-dimeth-oxy-chroman-4-ol.

Shaikh MM, Maguire GE, Kruger HG, du Toit K.

Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 23;67(Pt 3):o703. doi: 10.1107/S1600536811002066.

PMID: 21522447

 [(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]methanol 2.33-hydrate.

Chakka SK, McKay MG, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 23;67(Pt 3):o700. doi: 10.1107/S1600536811006052.

PMID: 21522445

 endo-11-(Dibenzyl-amino)-tetra-cyclo-[5.4.0.0.0]undecane-8-one.

Karpoormath R, Govender P, Govender T, Kruger HG, Maguire GE.

Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 12;67(Pt 3):o619. doi: 10.1107/S160053681100479X.

PMID: 21522375

 Pore formation in phospholipid bilayers by amphiphilic cavitands.

Elidrisi I, Negin S, Bhatt PV, Govender T, Kruger HG, Gokel GW, Maguire GE.

Org Biomol Chem. 2011 Jun 21;9(12):4498-506. doi: 10.1039/c0ob01236j. Epub 2011 Apr 20.

PMID: 21509358

Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease.

Makatini MM, Petzold K, Sriharsha SN, Soliman ME, Honarparvar B, Arvidsson PI, Sayed Y, Govender P, Maguire GE, Kruger HG, Govender T.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2274-7. doi: 10.1016/j.bmcl.2011.02.105. Epub 2011 Mar 1.

PMID: 21429747

 Optically active diaryl tetrahydroisoquinoline derivatives.

Naicker T, Govender T, Kruger HG, Maguire GE. Acta Crystallogr C. 2011 Mar;67(Pt 3):o100-3. doi: 10.1107/S0108270110053357. Epub 2011 Feb 8.

PMID: 21368406

 In vitro antifungal and antibacterial activities of pentacycloundecane tetra-amines.

Onajole OK, Coovadia Y, Govender T, Kruger HG, Maguire GE, Naidu D, Singh N, Govender P. Chem Biol Drug Des. 2011 Apr;77(4):295-9. doi: 10.1111/j.1747-0285.2011.01055.x. Epub 2011 Feb 22.

PMID: 21241455

 In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Abeta aggregation.

Bose PP, Chatterjee U, Hubatsch I, Artursson P, Govender T, Kruger HG, Bergh M, Johansson J, Arvidsson PI. Bioorg Med Chem. 2010 Aug 15;18(16):5896-902. doi: 10.1016/j.bmc.2010.06.087. Epub 2010 Jul 1.

PMID: 20659803

 Synthesis and NMR elucidation of novel pentacycloundecane-based peptides.

Altaib MS, Arvidsson PI, Govender T, Maguire GE, Makatini M, Onajole OK, Kruger HG.

Magn Reson Chem. 2010 Jun;48(6):435-42. doi: 10.1002/mrc.2598.

PMID: 20474021