Dr Johannes Bodenstein

Dr Johannes Bodenstein


Dr Johannes Bodenstein


 +27 (0)31 260 7500






Senior Lecturer

 Research Interests  

1. G protein-coupled receptor (GPCR) signal transduction mechanisms.

2. Proteomics.

3. Anti-inflammatory activities of components in natural products and synthetic derivatives.

4. Toxicological properties of components in natural products and synthetic derivatives.

5. Apoptosis and genotoxicity.

6. Antimicrobial additivism, synergism and antagonism.


Dr Johannes Bodenstein is a Senior Lecturer in Pharmacology.  His research interests include G protein-coupled receptor signal transduction mechanisms; Proteomics; Antimicrobial and anti-inflammatory activities of components in natural products and synthetic derivatives; Toxicological properties of components in natural products and synthetic derivatives; Apoptosis and genotoxicity.

List of Publications

  1. Brink CB, Harvey BH,Bodenstein J, Venter DP, Oliver DW.  (2004).  Recent advances in drug action and therapeutics: relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology.  British Journal of Clinical Pharmacology, 57:373-387.
  2. Bodenstein J, Brink CB, Venter DP.  (2005).  Phenoxybenzamine and benextramine, but not 4-diphenylacetoxy-N-[2-chloroethyl]piperidine hydrochloride, display irreversible non-competitive antagonism at G protein-coupled receptors.  Journal of Pharmacology and Experimental Therapeutics, 314:891-905.
  3. Bodenstein J, Sunahara RK, Neubig RR.  (2007).  N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.  Molecular Pharmacology, 71:1040-1050.
  4. Oosthuizen F, Bodenstein J, Reddy R.  (2009).  Use of concomitant medication in the treatment of schizophrenia. European Neuropsychopharmacology,19:S535-S536.
  5. Du Toit K, Buthelezi S,Bodenstein J.  (2009).  Anti-inflammatory and antibacterial profiles of selected compounds found in South African propolis. South African Journal of Science,105:470-472.
  6. Du Toit K, Drewes SE,Bodenstein J.  (2010).  The chemical structures, plant origins, ethnobotany and biological activities of homoisoflavanones.  Natural Product Research, 24:412-445.
  7. Katende-Kyenda N, Lubbe MS, Serfontein JHP, Truter I, Bodenstein J.  (2011).  Antiretroviral prescriptions with potential drug-drug interactions from general practitioners and specialists.  South African Medical Journal, 101:322-323.
  8. Du Toit K, Kweyama A,Bodenstein J.  (2011).  Anti-inflammatory and antimicrobial profiles of Scilla nervosa (Burch). Jessop (Hyacinthaceae).  South African Journal of Science,107:96-100.
  9. Shaikh MM, Kruger HG,Bodenstein J, Smith P, Du Toit K.  (2011).  Anti-inflammatory activities of selected synthetic homoisoflavanones.  Natural Product Research, 26:1473-1482.
  10. Brijlal N, Khoza N, Mbonane N, Meyiwa S, Moodley S, Parbhoo T, Pillay E, Lubbe MS, Bodenstein J.  (2011).  The attitudes and knowledge of pharmacists towards the use of herbal medicine.  South African Pharmaceutical Journal,78:35-37.
  11. Bodenstein J, Du Toit K.  (2012).  The susceptibility ofStaphylococcus aureus andKlebsiella pneumoniae to naturally derived selected classes of flavonoids.  In Antibacterial Agents, Chapter 4, p. 73-84.  InTech Open Access Publisher.
  12. Buthelezi S, Southway C, Govinden U, Bodenstein J, Du Toit K.  (2012).  An investigation of the antimicrobial and anti-inflammatory activities of crocodile oil.  Journal of Ethnopharmacology, 143:325-330.
  13. Essack SY, Naidoo I, Oosthuizen F, Bodenstein J, Brysiewicz P, Suleman F.  (2012).  Quality teaching and learning in the health sciences.  South African Journal of Higher Education,26:960-972.
  14. Pillay P, Phulukdaree A, Chuturgoon AA, Du Toit K,Bodenstein J.  (2013).  The cytotoxic effects of Scilla nervosa(Burch.) Jessop (Hyacinthaceae) aqueous extract on cultured HepG2 cells.  Journal of Ethnopharmacology, 145:200-204.
  15. Shaikh MM, Kruger HG, Smith P, Munro OQ, Bodenstein J, Du Toit K.  (2013).  Crystal structure and potent antifungal activity of synthetic homoisoflavanone analogues.  Journal of Pharmacy Research, 6:1-5.
  16. Shaikh MM, Kruger HG,Bodenstein J, Smith P, Du Toit K.  (2013).  Does nature provide the best therapeutic options?  Synthesis and anti-inflammatory activity of a naturally occurring homoisoflavanone and its enantiomer.  Journal of Pharmacy Research, 6:21-25.
  17. Shaikh MM, Koorbanally NA, Du Toit K, Ramjugernath D,Bodenstein J.  (2013).  3-Bromochroman-4-one.  Acta Crystallographica Section E,E69:o473.
  18. Du Toit K, Bodenstein J.  (2013).  Disposal of medical waste: A legal perspective.  South African Medical Journal, accepted, in press.