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Contact:

Tel:
+27 31 260 7358
Fax: +27 31 260 7792

Head of School:
pharmacyhos@ukzn.ac.za

Research:
pharmacyresearch@ukzn.ac.za

Undergraduate Issues:
pharmacyundergrad@ukzn.ac.za

Research

Catalysis and Peptide Research Unit

The interests of the unit’s research group span the disciplines of organic synthesis, asymmetric catalysis, peptide drug design and computational chemistry. Current projects are:

 •    Synthesis and evaluation of inhibitors targeting HIV and TB

 •    Synthesis of classes of chiral ligands and catalysts

 •    Experimental and theoretical research about the fundamental aspects of peptide folding. 

 •    Various computational projects into mechanistic effects of our synthetic projects.


Antimicrobial Resistance

Strategies for prevention and containment on antibiotic resistance based on surveillance, risk factors, clinical significance, infection control, pharmaco-economics and drug pharmacokinetics and pharmacodynamics
Molecular biology/Genetics of bacterial resistance


Molecular Modeling & Drug Design Research Group

Covers a wide range of computational and molecular modeling approaches with main focus on drug design and understanding of bio-related systems from different disciplines such as phytochemistry, pharmaceutics, medicinal chemistry, biochemistry, genetics and protein sciences.

Synthetic and Medicinal Chemistry Research Group 

Target Based Drug Design (HIV, TB and Cancer)
Strategies to develop new efficient synthetic methodologies to synthesize biologically important scaffolds.
Design and Synthesis of novel conducting polymers as potential Biosensors 
Design and development of nanoparticle-based electrodes. 

WHO Collaborating Centre for Pharmaceutical Policy and Evidence Based Practice

To conduct evidence based policy analysis and strengthen/develop conceptual innovation in the area of curriculum and pedagogy in pharmaceutical sciences and pharmaceutical policy related to particular topics of interest to WHO. The focus will be on evidence for low and middle income countries.

Protein systems in health & disease

Angiogenesis & in vitro tumour models
Neuro-psycho-immunology of auto-immune diseases
Indigenous anti-cancer candidate compounds
Transcription factors in diabetes


Molecular and clinical pharmacology research unit

Research theme: Metabolic syndrome in diabetes and Cardiovascular diseases

Novel Drug Delivery Systems

Design and Physicochemical/mechanical/molecular/biological evaluation of novel drug delivery systems e.g. sustained release pellets, nanoparticles, nanomicelles, nanofibers and buccal patches/films/tablets/microspheres/wafers.

HIV/AIDS/TB/IKS

1.Maximizing the therapeutic potential of clofazimine for tuberculosis: experimental and clinical approaches.
2.Indigenous knowledge systems and HIV/AIDS.


Researcher: Mr Olubunmi Adebiyi

Designation: Student  Department of Pharmacology in the School of Health Sciences

Study: Naringin Attenuates Oxidative Stress In Type I Diabetes Mellitus

Summary: Naringin is a chemical compound isolated from grapefruit. The study aimed to investigate the potential therapeutic benefits of naringin in ameliorating oxidative stress-induced cardiac and renal damage. Naringin has been identified to have a variety of effects ranging from antioxidant to anti-inflammatory and anti-mutagenic potentials. The study investigated the usefulness or otherwise of the antioxidant potentials of naringin in preventing or alleviating oxidative stress induced diabetic cardiomyopathy.



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