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Prof Breminand Maharaj

Person

Prof Breminand Maharaj

 

Telephone

+27 (0)31 2604335

Email

Maharajb4@ukzn.ac.za

Campus

Medical School

Research Interests

Cardiovascular Disease

Designation

Emeritus Professor

Biosketch

Dr Maharaj is professor of pharmacology at the University of Natal, Durban, South Africa.  He has contributed substantially to research in the black community in the developing world. 

His MD thesis was on "Some aspects of liver disease in black patients".  Papers on this subject (sample variability of liver biopsy) published in the Lancet have been quoted 67 times.  His PhD thesis on "Some aspects of the prevention of both recurrences of rheumatic fever and infective endocarditis" has led to guidelines for the prevention of both recurrences of rheumatic fever and infective endocarditis which may be easily implemented in developing countries. 

His main research interest, cardiovascular disease, includes 64 papers, 4 chapters in books, and 46 presentations both international and national, on hypertension, heart failure in blacks in pregnancy and are published in major international journals.

He is a member of the Medicine Control Council and the National Essential Drug List Committee of South Africa.  He has ably presented on behalf of the Nelson R.Mandela Faculty of Medicine, University of Natal, the faculty's submission to the Truth and Reconciliation Commission of South Africa.  He is a teacher in clinical pharmacology and clinical medicine since 1982 and has played an active role in curriculum reform in the medical school.

Dr Maharaj is currently actively involved in the practice of the art of True Light and the principles of the universe (Sukyo Mahikari) as a means of improving the quality of life and well-being of people.  His understanding of human spirituality and the concept of understanding the inner self is legion.  This ability has allowed him not only to be a collosus in the academia but to be a good caring human being.

It is also rumoured that Prof.Maharaj is the only known Maharaj of Brahmin stock who can bless people in Japanese.

List of Publications

PUBLICATIONS IN REFEREED JOURNALS

 

  1. Leary WP, Reyes AJ, Acosta-Barrios TN, Maharaj B. (1985). Captopril once daily as monotherapy in patients with hyperuricaemia and essential hypertension Lancet, i: 1277
  2. Maharaj B, Jogessar VB, Leary WP, Pudifin DJ. (1985) Typhoid fever and haemolytic anaemic in a Black patient with glucose-6-phosphate dehydrogenase deficiency. A case report. South African Medical Journal, 68: 110-111
  3. Maharaj B, Luvuno FM, Leary WP, Pudifin DJ. (1985). Conservative management of amoebic liver abscess complicated by pericardial extension. A case report .South African Medical Journal, 68: 189
  4. Leary WP, Reyes AJ, Acosta-Barrios TN, Maharaj B. (1985). Captopril once daily in patients with essential hypertension and hyperuricaemia South African Medical Journal, 68: 642-644
    1. Maharaj B, Cooppan RM, Maharaj RJ, Desai DK, Ranchod HA, Siddie-Ganie FM, Goqwana MB, MSA Ganie AS, Gaffar Leary WP, Pudifin DJ. (1986) Causes of hepatomegaly at King Edward VIII Hospital, Durban.  A prospective study of 240 Black patients. South African Medical Journal, 69: 183-184
    2. Maharaj B, Maharaj RJ, Leary WP, Naran AD, Cooppan RM, Pirie D, Pudifin DJ. (1986). Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. Lancet, i: 523-525
    3. Maharaj B, Kalideen JM, Leary WP, Pudifin DJ. (1986). Carcinoma of the prostate with multiple osteolytic metastases simulating multiple myeloma. A case report South African Medical Journal, 70: 227-228
    4. Maharaj B, Maharaj RJ, Leary WP, Naran AD, Cooppan RM, Pirie D, Pudifin DJ. (1986). Sampling variability in percutaneous liver biopsy. Lancet, i: 975
    5. Maharaj B, Singh GP, Pudifin DJ. (1986). Pulmonary alveolar proteinosis. A case report. South African Medical Journal, 70: 692-693

10.  Maharaj B, Dyer RB, Leary WP, Arbuckle DD, Armstrong TG, Pudifin DJ. (1987). Screening for  rheumatic  heart disease amongst Black schoolchildren  Journal of Tropical Pediatrics, 33: 60-61

11.   Maharaj B, Leary WP, Pudifin DJ. (1987). A prospective study of hepatic tuberculosis in 41 Black patients Quarterly Journal of Medicine, 63: 517-522

12.  Maharaj B, Hammond MG, Appadoo B, Leary WP, Pudifin DJ.  (1987). HLA-A, B, DR and DQ antigens in Black patients with severe chronic rheumatic heart disease Circulation, 76: 259-261

13.  Maharaj B, Luvuno FM, Leary WP, Pudifin DJ.  (1987). The conservative management of amoebic liver abscess complicated by thoracic extension. Tropical and Geographical Medicine, 39: 299-302

14.  Leary WP, Reyes AJ, van der Byl K, Maharaj B. (1987). Comparative antihypertensive effects of ketanserin and a ketanserin-hydrochlorothiazide combination administered once daily. Journal of Cardiovascular Pharmacology, 10 (Suppl.3): S127-S134

15.  Maharaj B, Leary WP. (1988). Strategies for reducing aminoglycoside toxicity. South African Medical Journal, 73: 72-74

16.  Van der Byl K, Maharaj B, Leary WP. (1988). A comparison of captopril and atenolol in addition to hydrochlorothiazide for the treatment of hypertension. South African Medical Journal, 74: 425

17.  Leary WP, Reyes AJ, Maharaj B. (1988). Effects of atenolol, propranolol, and tertatolol on urinary excretion of water and solutes in healthy subjects. Current Therapeutic Research, 44: 630-640

18.  Reyes AJ, Leary WP, van der Byl K, Maharaj B. (1988). In: Reyes AJ and Leary WP (Eds). Progress in Pharmacology: Clinical Pharmacology and Therapeutic Uses of Diuretics.  Stuttgart, New York: Gustav Fischer Verlag, 6(3); 245-266

19.  Maharaj B. (1988). Diuretics in Cirrhotic Ascites. Renal excretory pharmacodynamics of diuretics in man: comparison between hydrochlorothiazide and torasemide furosemide, In: Reyes AJ and Leary WP (Eds).Progress in Pharmacology: Clinical Pharmacology. and Therapeutic Uses of Diuretics. Stuttgart, New York: Gustav Fischer Verlag, 6(3); 83-151

20.  Maharaj B. (1988). Diuretics in Renal Failure. In: Reyes AJ and Leary WP (Eds).  Progress in Pharmacology: Clinical Pharmacology and Therapeutic Uses of Diuretics. Stuttgart, New York: Gustav Fischer Verlag, 6(3); 267-288

21.  Maharaj B. (1988). . Drug interactions with Diuretics. In: Reyes AJ and Leary WP (Eds) .Progress in Pharmacology: Clinical Pharmacology and Therapeutic Uses of Diuretics. Stuttgart, New York: Gustav Fischer Verlag, 6(3); 289-315

22.  Maharaj B. (1989). Calcium channel blockers in hypertension. International Journal of Cardiology, 25: 1-6

23.  Maharaj B, Bhoora IG, Patel A, Maharajh J. (1989). Ultrasonography and scintigraphy in liver disease in developing countries. Lancet, ii: 853-856

24.   Leary WP, Reyes AJ, van der Byl K, Maharaj B. (1989). Antihypertensive effects of clopamide administered alone and in combination with pindolol or with reserpine and dihydroergocristine. Current Therapeutic Research, 46:1224-1235

25.  Leary WP, Maharaj B. (1990) Comparison of felodipine and hydrochlorothiazide for the treatment of mild to moderate hypertension in Black Africans. Journal of Cardiovascular Pharmacology, 15 (Suppl.4); S91-S93

26.  Maharaj B, Hammond MG. (1990). HLA A, B, DR and DQ antigens in black patients with idiopathic dilated cardiomyopathy. American Journal of Cardiology, 65; 1402-1403

27.  Maharaj B. (1990). Ultrasonography and scintigraphy in liver disease in developing countries Biomedicine and Pharmacotherapy, 44; 439-440

28.  Leary WP, Reyes AJ, Maharaj B, van der Byl K. (1991). Time course of the blood pressure response to oral isradipine in uncomplicated mild to moderate essential hypertension.  American Journal of Hypertension, 4; 147S-149S

29.  Maharaj B. (1991). The causes of congestive heart failure in black patients at King Edward VIII Hospital, Durban Cardiovascular Journal of Southern Africa, 2; 31-32

30.  Maharaj B, Pillay S. (1991). Tru-Cut needle biopsy of the liver: importance of the correct technique. Postgraduate Medical Journal, 67; 170-173

31.  Khedun SM, Leary WP, Lockett CJ, Maharaj B. (1991). Changes in myocardial electrolytes and ventricular threshold induced by alcohol feeding in laboratory rats. Japanese Heart Journal, 32; 373-379

32.  Leary WP, Maharaj B, van der Byl K. (1991). Isradipine in the treatment of mild to moderate essential hypertension South African Medical Journal, 80; 322-323

33.  Maharaj B, Pillay S, Padaychi T. (1991) Circulating CA-195 in hepatocellular carcinoma and metastatic hepatic carcinoma Tropical and Geographical Medicine, 43; 329-331

34.  Khedun S M, Maharaj B, Lockett C J, Leary W P (1991) The effect of hexane on ventricular fibrillation threshold levels in the isolated perfused rat heart Toxicology, 71; 145-150

35.  Maharaj B, Van der Byl K.(1992) A comparison of the acute hypotensive effect of a single dose of nifedipine 5 mg and 10 mg American Heart Journal, 124; 720-725

36.  Khedun SM, Maharaj B, Leary WP (1992) Influence of ethyl alcohol when given alone or in combination with potassium and or/ magnesium supplements on ventricular fibrillation threshold levels in laboratory rats. Magnesium Research, 5; 115-120SEE 32

37.  Khedun SM, Maharaj B, Leary WP (1992) The effects of supra therapeutic doses of rifampicin on liver function in the perfused rat liver International Journal of Experimental Pathology, 73; 449-453

38.  Pillay S, Maharaj B (1992) The use of drug level measurements in adult patients receiving theophylline, anti-epileptic drugs and amikacin. The Central African Journal of Medicine, 38; 331-333

39.   Maharaj B, Bhoora IG (1992) Complications associated with percutaneous needle biopsy of the liver when one, two or three specimens are taken. Postgraduate Medical Journal, 68; 964-967

40.  Maharaj B, Moodley J, Khedun SM (1993). Plasma renin activity and aldosterone levels in black patients with severe pre-eclampsia. Cardiovascular Journal of Southern Africa, 4; 5-6

41.  Yap EPH, Cooper K, Maharaj B, McGee JO’D (1993). p53 codon 249ser hot-spot mutation in HBV-negative hepatocellular carcinoma. Lancet, 341; 251

42.  Maharaj B, Van der Byl K (1993) Journal of Human Hypertension, 7; 447-450. A randomised double blind comparative study of the efficacy and safety of hydroflumethiazide and reserpine and chlortalidone and atenolol in the treatment of mild to moderate hypertension in black patients

43.  Maharaj B,van der Byl K.(1993) A comparative study of Isradipine SRO and Enalapril in Black Patients with Mild to Moderate Hypertension American Journal of Hypertension, 6; 805-815

44.  Maharaj B, Khedun SM,Gregory M, Naicker T(1993) The effect of hexane on rat myocardium: a morph metric and morphological study. International Journal of Experimental Pathology, 74; 145-150

45.  Khedun SM, Maharaj B, Leary WP(1993) The effect of therapeutic doses of paracetamol on liver function in perfused rat liver. Journal of Pharmacy and Pharmacology, 45; 566-569

46.  Maharaj B, Pillay S.(1993) The value of screening for hypertension and diabetes mellitus at worksite Cardiovascular Journal of Southern Africa,4(3);102-105

47.  Khedun SM, Maharaj B, Leary WP, Naicker T (1993) The effect of isoniazid on liver function in the perfused rat liver Israel Journal of Medical Sciences 29(12); 791-794

48.  Maharaj B, Moodley J, Khedun SM, Madhanpall N, van der Byl K (1994) Intravenous isradipine in the management of severe hypertension in pregnancy. A pilot study Blood Pressure, 3(Suppl 1); 54-56

49.  Bux C, Snyman C, Chuturgoon AA, Dutton MF, Ramdial PK, Maharaj B (1994)  Immunocytochemical studies on aflatoxin B1 in human hepatocellular carcinomas- A preliminary study. Proceedings of the Electron Microscopy Society of Southern Africa 25: 50

50.  Maharaj B, Khedun SM, Moodley J, van der Byl K (1994) Intravenous isradipine in the management of severe hypertension in pregnant and non-pregnant patients. A pilot study. American Journal of Hypertension, 7; 61S-63S

51.   Khedun SM, Maharaj B, Naicker T (1995) The effect of hexane on liver function and liver morphology in the rat Toxic Substances Mechanisms Journal, 14(4): 271-279

52.  Khedun SM, Naicker T, Maharaj B (1995) Zinc, hydrochlorothiazide and sexual dysfunction Central African Journal of Medicine. 41(10): 312-314

53.  Khedun SM, Maharaj B, Naicker T (1995) Hexane cardiotoxicity- an experimental study. Proceedings of the Electron Microscopy Society of Southern Africa 25: 50

54.   Khedun SM, Naicker T, Maharaj B, Rapiti N, Bhoola KD, Naidoo S (1995) Methylated spirits abuse. Proceedings of the Electron Microscopy Society of Southern Africa.25:50

55.  Khedun SM, Maharaj B, Naicker T (1996) Hexane cardiotoxicity- an experimental study. Israel Journal of Medical Sciences 32: 123-128

56.  Khedun SM, Maharaj B, Naicker T (1996) The effect of low dose versus a conventional dose of hydrochlorothiazide on ventricular fibrillation Threshold and electrolyte levels in laboratory rats. Brazilian Journal of Medical and Biological Research 29: 1373-1378

57.   Maharaj B, Moodley J, Khedun SM, van der Byl K, Rapiti N (1997) A comparative study of intravenous isradipine and dihydralazine in the treatment of severe hypertension of pregnancy in black patients. Hypertension in Pregnancy 16(1):1-9

58.  Khedun SM, Moodley J, Maharaj B, Naicker T,  (1997 Drug management of hypertensive disorders of pregnancy.  Pharmacology and Therapeutics 72(2): 221-258

59.  Maharaj B, Khedun SM, Hammond MG, van der Byl K (1997) HLA-A, B, DR and DQ antigens in Indian patients with severe chronic rheumatic heart disease Japanese Heart Journal 38 (5): 1-6

60.  Maharaj B, Khedun SM, Hammond MG (1997) HLA-A,B,DR and DQ antigens in Black patients with hepatocellular carcinoma East African Medical Journal 74 (11) : 705-707

61.  Maharaj B, Khedun SM, Hammond MG, van der Byl K (1998) HLA-A, B, DR and DQ antigens in Black patients with infective endocarditis South African Medical Journal 88(Suppl 1): C10-C12

62.  Sega R, on behalf of Eprosartan Multinational Study Group (1999) Efficacy and Safety of Eprosartan in Severe Hypertension. Blood Pressure 8: 114-121

63.  Khedun SM, Maharaj B, Moodley J (2000) The effect of antihypertensive drugs on the unborn child; What is known and how should this influence prescribing? Paediatric Drugs 2(6): 419-436

64.  Khedun SM, Moodley J, Maharaj B, Naicker T (2000) How South African obstetricians manage hypertensive disorders of pregnancy. A questionnaire study. South African Medical Journal 90(2): 156-160

65.  Mathibe LJ, Maharaj B (2006) Implementation of the principles of holistic patient care at the Nelson R Mandela School of Medicine: medical students' perspective. Medical Teacher 28(8): 744-745

66.  Rambiritch V, Pillai, G, Maharaj B, Robertson, LI (2007). Glibenclamide - what dose? South African Medical Journal 97(7): 475

67.  Manjra AI, Nel H, Maharaj B (2009). Effect of desloratidine on patients with allergic rhinitis and exercise-induced bronchoconstriction: a placebo controlled study. Journal of Asthma 46(2): 156-159

68.  Maharaj B, Coovadia Y, Vayej AC. (2012) An investigation of the frequency of bacteraemia following extraction, toothbrushing and chewing. CardioVascular Journal of Africa.23(6):340-344

69.  Maharaj B, Vayej AC. (2012) Oral health of patients with severe rheumatic heart disease. CardioVascular Journal of Africa.23(6): 336-339

70.  Maharaj B, Coovadia Y, Vayej AC. (2012) A comparative study of amoxicillin, clindamycin and chlorhexidine in the prevention of post- extraction bacteraemia.  CardioVascular Journal of Africa.23(9):491-494

 

71.  Maharaj B, Parrish A. (2012). Editorial: Prevention of infective endocarditis in developing countries. . CardioVascular Journal of Africa. 23(6): 303-305

72.  Parrish A, Maharaj B. (2012). Prevention of infective endocarditis in developing countries – justifiable caution. South African Medical Journal 102(8): 652-654

73.  Maharaj B, Vayej AC (2013). Awareness and knowledge of prophylaxis for infective endocarditis in patients with severe rheumatic heart disease. South African Dental Journal. 68(2): 68-71

 

 


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